Abstract:A variety of 1,3-selenazoles and related compounds, including 2,4,5-trisubstituted, 2,4-disubstituted, 4,5-disubstituted, 4-substituted 1,3-selenazoles and parent unsubstituted 1,3-selenazole and 1,3,4-6H-selenadiazines, were prepared. Most syntheses rely on the application of selenocarboxylic amides, selenourea and related building blocks which are conveniently available by reaction of the corresponding oxygen analogues with P₄Se₁₀. 1,3-Selenazoles are of pharmacological relevance.

Review: Synlett 2022, 33, 728-736.

Period of investigation: 2002 - 2015

Keywords: heterocycles; cyclizations